May 29, 2025

Over 40 and a baby — what are the real chances?

Wanting a child over 40 is not a whim, it is not a delay, it is not selfishness. It is a wish — sometimes long awaited, sometimes hard to come true. But completely human.
However, the reality is this: age does matter. And no matter how advanced we are in reproductive medicine, we cannot ignore biology. We can only understand it — and work with it.

What changes after 40?

- The number of eggs is greatly reduced;
- The quality of the eggs also decreases - especially genetically;
- The risk of chromosomal abnormalities increases;
- Menstrual cycles become more unpredictable;
- Reduces sensitivity to hormonal stimulation.

This does not mean that it is impossible. It means that the path is more specific and must be individually planned.

What are the real chances of pregnancy after 40?

In vitro with own eggs:
- At 40—41 years: ~15— 20% chance of achieving clinical pregnancy;
- At 42—43 years: ~ 5-10%;
- Over 44 years: below less than 2%.

When donor eggs are used, however, the success rate is close to that of women under 35 years of age — about 50— 60% per transfer.

What can we do to increase the chance?

- Maximum good preparation — hormonal and metabolic balance;
- Short protocols with high individualization;
- Use of culturing to blastocyst and PGT;
- Focus on the quality of the endometrium;
- Freeze-all strategy as needed;
- Psycho-emotional support and realistic planning.

And when to discuss a donor egg?

- In several unsuccessful attempts with own eggs;
- With repeated poor response to stimulation;
- In case of genetic abnormalities or depleted reserve;
- When a woman wishes to significantly increase the chance of a healthy baby with a shorter path.

Truth and Hope at the Same Time

The truth: as you get older, the chance of pregnancy with your own eggs decreases dramatically.
The hope: in vitro technology, donor programs and a personalized approach make parenting possible even after 40.

In our clinic, we treat with respect the years, experiences and stories that every woman brings with her. Age is not the enemy; it is a factor. And with the right team and a real strategy, the path to the baby can also be your way.

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