NACE and NACE 24

What are the NACE and NACE 24 tests?

The NACE and NACE 24 tests are non-invasive prenatal screening tests — completely safe for you and your baby. A simple blood draw from the mother allows the detection of free fetal DNA circulating in the mother's bloodstream through next-generation sequencing (NGS) technology and a patented bioinformatics analysis tool. The NACE and NACE 24 tests check for the presence of chromosomal abnormalities in the baby. Humans have 23 pairs of chromosomes and a total of 46 chromosomes (two copies of each pair). The first 22 pairs are numbered from 1 to 22. The last pair determines our gender. Girls have two X chromosomes, and boys have one X chromosome and one Y chromosome. Health and developmental problems arise if there is a missing or extra chromosome.

When there is an extra copy of a chromosome (i.e., three copies, instead of two), this is called “trisomy”.

Quali opzioni sono disponibili?

IS BORN: Detects abnormalities in chromosomes 21, 18, 13 and the most common abnormalities in sex chromosomes (X and Y).

GEBOREN 24: Analyzes the complete set of chromosomes and standard karyotype resolution. It identifies deletions and duplications that are associated with clinically significant genetic syndromes.

Todo lo que se a es un esempio de sangue venível — samo como cualquier test de sangue routină.

What are the main advantages of NACE and NACE 24?

• Painless, non-invasive prenatal screening, without any risk to the fetus;

• NACE detects abnormalities in chromosomes 21, 18, 13, X and U;

• NACE 24 has the same characteristics as NACE, in addition to the NACE information, it tests all chromosomes and detects trisomies in chromosomes 9 and 16 that underlie the presence of miscarriages in the first trimester of pregnancy, as well as identifying six microdeletions associated with the main genetic syndromes (DiGeorge syndrome, Velo-cardio-facial syndrome, 1p36 delition syndrome, Angelman syndrome, Prader-Willi syndrome, Cat's cry syndrome, Wolf-Hirschhorn syndrome);

• NACE is applicable for single and multiple pregnancies and NACE 24 only for single pregnancies;

• 99.9% recognition of Down syndrome;

• False-positive score index < 0.1% for Down syndrome;

• Valid in patients with a donor egg;

• Valid for all races, ethnicities and body mass indexes;

• A;

• Includes genetic counseling;

• The result is ready in 15 days;

• Includes confirmation by QF-PCR in case of a positive result and a second blood test at no additional cost in case of uninformative results;

• Significantly lower value compared to other similar diagnostic products.

Should I take the NACE or NACE 24 test?

• Testên ji bo hemî jinan têne pêşniyar kirin ku di zarokên xwe yên pêşerojê de nebûna nexweşiyên kromozomîkî yên herî gelemperî, bêyî ku wî di lêdana biopsiya chorionîk û amniocentesis de xeternak bigirin.

• A w. They are also recommended when achieving pregnancy in women of advanced reproductive age.

• A test can be performed in any pregnant woman, as well as in pregnancies achieved through in-vitro techniques, including pregnancies from a donor egg.

What kind of result will I get?

A. When the test shows that there is a high risk of a chromosomal abnormality, your doctor will inform you about other tests that can confirm this diagnosis.

How are NACE and NACE 24 performed?

• Consult with our specialist gynecologist;

• A sample of venous blood is taken;

• The sample is sent for examination;

• The result is ready in 15 days.

Application of NACE in Bulgaria:

For the first time in Bulgaria, the innovative NACE® prenatal screening is implemented in the Specialized Hospital for Obstetrics, Gynecology and Reproductive Medicine “Sofia”.

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