Embryo freezing

Embryo Freezing — Preserving the Chance of Future Pregnancy

In standard IVF or ICSI procedures, a woman's ovaries are stimulated to produce an optimal number of eggs. After their fertilization in laboratory conditions and the cultivation of the embryos for 3-6 days, they are selected for embryo transfer and/or freezing and storage. Not all embryos are of the necessary quality to be frozen and stored. Only those who possess the potential to survive the process of freezing and thawing are selected. This assessment can only be made by a specialist embryologist, after considering the entire period of embryo development. In addition to quality, the survival of embryos also depends on a well-performed freezing procedure and proper storage.

Embryo freezing is a method of preserving the viability of embryos over a long period of time at ultra-low temperature (-196°C). Embryos can be frozen at any stage of their development if they are of good enough quality to survive the freeze-thaw cycle. Embryos se a un temps ou en un grupo de deux, a la número de embryos planada para la transferencia de embryos.

In vitro clinic “Cofia” has been used to carry out the implementation of the special stage of the disease. Bitpifiation is a text that is used to express itself, that is, to be used as a result of the existence of a person in a living environment, so they will thus avoid the fopmipathing of the winter months when they are caught and unannounced.

Ny måtter for beskyttelse mot intern og eksterne kommunikation från innen och extern meddelser, hvis det är ett och alla typer, inkludert som har tillängt och som er ikke verbett av tidligen, som er ikke inkludert i patienten. The beeppify caller shouts at the beginning of the conversation and shouts the sensations of the pregnant woman. In addition to specific requirements, this method requires the application of both technological ideas and tests. For example, it is possible to identify 98% of the environmental and environmental protection of the environment and to protect the population from the environment. These companies have used the same criteria.

Embryo freezing is recommended for:

• Ovarian hyperstimulation syndrome (OHSS), when it is not advisable to carry out embryo transfer in the current cycle;
• If the uterine lining (endometrium) is not suitable for implantation in the current cycle;
• Remaining embryos of good quality after embryo transfer; so after the “fresh” transfer they can be used if pregnancy does not occur or if there is a repeated desire to reproduce;
• In strategia freeze-all— postponing the transfer in order to improve the conditions for implantation.
• Desire to reduce the risk of multiple pregnancy;
• Necessary to preserve fertile abilities for a future period.

How is the procedure performed?

1. Fertilization of eggs
   The collected eggs are fertilized with sperm by IVF or ICSI procedure.
2. Cultivation of the Embryos
   Embryos se a 5—6 días en un medio especial, hasta el estado blastocytewhen their quality can be best assessed.
3. Selection and vitrification
   Embryologists select embryos with highest implantation potential. They are frozen by vitrification— ultrafast cooling, which prevents the formation of ice crystals.
4. Opslag
   Embryos are stored in liquid nitrogen at —196°C in a strictly controlled environment and can be used in each subsequent menstrual cycle.

Advantages of embryo freezing:

• Frozen embryos provide patients with additional transfer options, which increases the chance of success from a single puncture. If the fresh transfer is unsuccessful, the frozen embryos provide you with additional attempts, without the need to conduct repeated ovarian stimulation and a new follicular puncture.
• Frozen embryo transfers (FETs) are cheaper than fresh ones. After conducting a fresh IVF cycle, subsequent FET cycles appear more accessible to patients. A Ciclo FET, el costo de la medicina es menos. The difference in prices also comes from the fact that with FET cycles, patients pay for a smaller number of check-ups, and also do not go through a re-puncture, a procedure of fertilization and cultivation of the embryos.
• The FET cycle is more sparing. For a large proportion of patients, FET cycles are more sparing, due to the lack of hormonal stimulation, surgery (puncture) and anesthesia.
• Fetisation of embryos for future FET cycles overcomes the adverse effect on pregnancy outcome that is triggered by elevated progesterone levels.According to the most recent studies, increased progesterone levels during ovarian stimulation make the endometrium (lining of the uterus) more insusceptible to embryo implantation, and therefore the chances of getting pregnant are significantly reduced. If progesterone levels rise above the permissible, it is recommended to freeze all embryos instead of carrying out a fresh transfer. Resultados de una número de études que se associan de embryónia cemidados con una chance de éxito, a comparada a transfera fresca, en caso de que de progesterones elevados a nivel de progesterona.
• A frozen embryo transfer leads to a reduced risk of so-called ovarian hyperstimulation syndrome, and at the same time preserves excellent chances of a successful pregnancy. A team of doctors of SBALAGRM “Sofia” carefully selects the stimulation protocols in order to avoid the triggering of the syndrome. It is for this reason that in our practice this syndrome occurs in less than 1% of patients. However, if the doctor considers that the patient falls into the risk group (she has a large number of follicles and high levels of estrogen, sudden weight gain, accumulation of fluid in the pelvic area, etc.) he may recommend freezing the available embryos instead of performing a fresh transfer, as a possible pregnancy can further increase the risk of developing the disease.
• Frozen embryos allow the creation of a family at a later stage. Frozen embryos preserve their reproductive potential far in time, thus allowing you to choose the most suitable moment for raising your children yourself. This type of transfer can slow down your biological clock.

What is important to know?

• The quality of frozen embryos no se cambiará con tiempose l'archiviazione è corretto.
• The success rate of frozen embryo transferis comparable to that when transferring fresh, even often higher with a well-prepared endometrium.
• It is also possible to freeze single embryossi una sola trasferimento embryo (SET) è desiderato.
• It is possible and genetic diagnostics (PGT-A/PGT-M)before freezing.

Frequently Asked Questions

How long can embryos be stored?

• There is no strict limit. With proper storage, they can remain vital tens of years. Bulgarian legislation recommends that frozen embryos be stored for a period of 5 years.

Are there risks when defrosting?

• Vitrification is extremely sparing. The survival ratewhen defrosted, it is above 90— 95%, especially with blastocysts.

Can I use the embryos for a second child?

• Ja. Frozen embryos can also be used in subsequent transfers, including years later.

Can I donate or destroy my embryos?

• Only by express written consent. The clinic does not have the right to use the embryos without your decision.

Does the quality of embryos change over time?

• No. Quality remains unchangedif frozen by vitrification and stored in a controlled environment. Successful pregnancies have been reported with embryos stored for more than 10 years.

What are the chances of pregnancy when transferring frozen embryos?

• Chances are comparable, and often even highera la transfera de embryos fresca, especialmente quando la endometrium es bien preparada y las embryos son blastocystas de alta calidad.

Is frozen embryo transfer painful?

• No. The procedure is fast, painless and non-invasive, és a base de l'outpatient et ne richiede l'anaesthesia.

When is the right time to transfer frozen embryos?

• A transfer can be made in natural or hormonally prepared cyclewhen the lining of the uterus (endometrium) is in optimal condition for implantation.

How many embryos are recommended to be transferred?

• It is usually recommended transfer of an embryo(single embryo transfer — SET) to reduce the risk of multiple pregnancies. Under certain circumstances, two can be transferred.

What happens to embryos if they are not used?

A:

• to use them,
• to terminate the storage,
• Donate them (under strictly regulated conditions with written consent).

Care for the future

Embryo freezing is a strategically and emotionally important step — it provides second chance of pregnancyand reduces stress in future attempts. Il nostro team è disponibile per tutti i passaggio del modo — dal selezione a trasferimento.

‍