EndomeTRIO

EndoMetrio is a powerful tool for personalized reproductive medicine. It allows us to understand not only when, but also under what conditions the embryo transfer must take place in order for it to be successful.

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Криолечение

Endometrio — comprehensive molecular diagnostics of the endometrium

Endometrio is an advanced combined test that provides a complete picture of the state of the uterine mucosa by combining three key analyzes:

  • ERA — to determine the implantation window;
  • EMMA — for endometrial microbiome analysis;
  • ALICE — for the detection of chronic inflammatory infections.

This is the most modern and personalized approach to diagnosing the causes of failed implantation and early reproductive losses.

What is Endometrio?

Endometrio is a complex molecular test that is performed through a single endometrial biopsy. Using qPCR technology (quantified polymerase chain reaction), the following are examined:

  • The gene expression determining the exact moment of receptivity (ERA);
  • Bacterial profile and dominance of beneficial bacteria (EMMA);
  • The presence of pathogenic bacteria, causative agents of chronic endometritis (ALICE).

When is Endometrio recommended?

The test is highly recommended for:

  • More than two failed embryo transfers, despite good embryos;
  • Unexplained sterility;
  • Early miscarriages;
  • Suspicions of inflammation or microbial imbalance;
  • Preparing for a donor egg or a limited number of embryos.

What answers does Endometrio give?

  1. ERA (Endometrial Receptivity Analysis) — Determines whether the endometrium is receptive on the day of the transfer or needs a custom shift.
  2. EMMA (Endometrial Microbiome Metagenomic Analysis) — Analyzes whether more than 90% of bacteria are Lactobacillus spp. — beneficial bacteria that create a protective and receptive environment.
  3. ALICE (Analysis of Infectious Chronic Endometritis) — Detects the presence of harmful microorganisms such as E. coli, Mycoplasma, Gardnerella, etc.

How is it carried out?

  1. Endometrial biopsy — a small fragment of the lining of the uterus is taken, usually in a hormonally prepared cycle.
  2. Sending to a specialized laboratory — one sample is analyzed for all three components.
  3. Detailed report — the results are combined and provide a clear recommendation for next steps.

What do we offer in our clinic?

At Invitro Clinic “Sofia” we apply the Endometrio test in women with repeated failures or in case of need of a thorough evaluation of the endometrial environment. We provide:

  • Accurate planning of the day for biopsy;
  • Detailed interpretation of the results;
  • Treatment of established infections or imbalances;
  • Personalized transfer for maximum chance of success.

Why choose Endometrio?

  • Only one biopsy — three valuable tests;
  • Personalized transfer (pET) with scientific justification;
  • High diagnostic value in failures for no apparent reason;
  • Combining immunological, microbiological and chronobiological factors.

Conclusion

EndoMetrio is a powerful tool for personalized reproductive medicine. It allows us to understand not only when, but also under what conditions the embryo transfer must be carried out in order for it to be successful. This is the new generation of diagnostics — precise, targeted and effective.

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