Halosperm test
Halosperm is a simple, reliable and informative test that measures the degree of DNA fragmentation in sperm — an indicator that is invisible in a standard spermogram, but plays a key role in the quality of male fertility.
Halosperm test — evaluation of sperm DNA fragmentation
Halosperm is an established laboratory test that measures the degree of DNA fragmentation in sperm — an indicator that is invisible on a standard spermogram, but plays a key role in the quality of male fertility.
What is DNA fragmentation?
Each sperm carries in its head DNA with the genetic information necessary for fertilization and healthy development of the embryo. When this DNA is damaged or “torn”, we speak of fragmentation. It can be the result of:
- Oxidative stress;
- Inflammatory processes;
- High temperature (varicocele, work in a hot environment);
- Aging of spermatozoa;
- Harmful habits (smoking, alcohol, drugs);
- Bad lifestyle and stress.
Why is the Halosperm test important?
In men with normal spermograms but with fragmented DNA:
- The chance of natural conception is lower;
- Fertilization may occur, but the embryo stops developing;
- The risk of miscarriage is increased;
- It is possible that the embryos look good morphologically but are genetically unstable.
How is the test performed?
- Collection of semen sample — after 2—5 days of sexual abstinence;
- Sample processing in the laboratory;
- Halosperm staining — a “halo” is created around the head of normal spermatozoa;
- Microscopic analysis — hundreds of sperm are counted to determine the percentage of DNA fragmentation.
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How is the result interpreted?
- The halosperm test is especially useful with a normal spermogram, but unsuccessful IVF attempts or repeated miscarriages.
- DNA fragmentation can be positively influenced by lifestyle change and antioxidant therapy.
- With a high percentage of fragmentation, an individualized plan with ICSI and additional laboratory selection is recommended.
When is Halosperm recommended?
- Repeated unsuccessful IVF attempts;
- Miscarriages in the partner;
- Age over 40 years;
- Environmental influences (high temperature, toxins);
- Previous poor fertilization results or poor quality of embryos;
- Search for the causes of idiopathic infertility
- PIs declared to be published (with the purpose of this type, that the population is the same as the main target of the DHK Fpagmentation).
What do we offer in our clinic?
In the Invitro Clinic “Sofia” Halosperm test is performed in a modern andrological laboratory by experienced specialists. We provide:
- Consultation on the results of the study;
- Possibility of additional tests (SAT, hormone profile, microbiology)
- Antioxidant therapy plan or additional laboratory techniques (IMSI, ZyMOT)
Conclusion
Halosperm is an easy, reliable and informative test that gives valuable information about the invisible causes of male infertility. It is part of the modern personalized approach to treatment and helps many couples achieve their dream of having a child.